Istavel 25mg
Available Dosages
| SKU | 1010 |
|---|---|
| Generic For | Januvia |
| Strength | 25mg |
| Manufacturer | Sun Pharma |
| Active Ingredient | Sitagliptin |
| Pack Size | Qty | Price Per Pill or Unit | Price | Cart | |
|---|---|---|---|---|---|
| 50 Tablet/s | US$ 0.44 | US$ 22.00 | |||
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| 100 Tablet/s | US$ 0.30 | US$ 30.0032%US$ 44.00 | |||
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Istavel 25mg – Affordable Januvia Alternative for Type 2 Diabetes
Istavel 25mg can be useful as a monotherapy or in combination with other anti-diabetic medicines to control blood sugar (glucose) in patients suffering from type 2 diabetes mellitus. You will need to take it in addition to your existing anti-diabetic medication under medical supervision. Istavel, along with your other diabetes medicine, can help better manage your blood glucose levels. To avoid long-term complications, it is essential to maintain normal sugar levels.
Sitagliptin, the main ingredient of the medicine, is a DPP-4 inhibitor that acts by increasing the level of a substance in the body that helps lower blood sugar levels. The oral agent approved by the FDA for use in the management of patients with type 2 diabetes whose blood glucose level cannot be controlled effectively with certain medications. Taking this anti-diabetic agent regularly along with a healthy lifestyle (eating a balanced diet and regular physical activity) can lower the risk of getting serious, life-threatening complications such as nerve damage, eye problems, stroke, kidney problems, and heart disease.
Istavel 25mg (Sitagliptin Tablet)
Consumption of alcohol can interfere with the blood glucose levels. Avoid drinking alcohol while taking Istavel 25mg without first discussing with your health care specialist. You should inform your healthcare specialist about all types of medications, including illegal, herbal, dietary, or nutritional supplements, especially:
- Insulin
- Lanoxicaps or digoxin
- Certain oral anti-diabetic medications include glipizide, tolazamide, chlorpropamide, glimepiride, tolbutamide, and glyburide.
The antihyperglycemic agent is not suitable for patients who are hypersensitive to Sitagliptin or any of the formulation's ingredients. There are no adequate data on the use of Istavel 25mg in pregnant women. The potential risk to humans is not known; the sitagliptin formulation should not be used during pregnancy. Moreover, it is unknown whether the medication is excreted in breast milk. Animal research studies have shown the excretion of Istavel in breast milk. Hence, the anti-diabetic agent should not be used during breastfeeding.
Istavel 25mg (Sitagliptin Tablet)
The most observed side effects of Istavel 25mg may include back pain, headache, stuffy or runny nose, stomach pain, nausea, joint or muscle pain, diarrhoea, etc.
Some serious adverse effects associated with the usage of Sitagliptin are pancreatitis (inflammation of the pancreas) and allergic reactions. Symptoms of an allergic reaction include skin peeling, eye burning, sore throat, chills, fever, blistering, loose skin, severe rash, and trouble breathing or swallowing. Seek immediate medical attention if you experience any serious side effects.
Istavel 25mg
Always remember that Istavel is only applicable for patients with type II diabetes; it is not suitable for patients with type I. Take one tablet daily at the same time. You can take it with or without food. Swallow the tablet with a glass of water. Do not split, crush, or chew the tablet before swallowing. The medicine doesn't always need to work for all patients. You should consult with your healthcare expert before starting treatment with this anti-diabetic agent. The correct dosage commonly depends on the patient and the condition being treated. You are not allowed to adjust your dosage without the approval of your health care specialist. The medicine is only for use as prescribed and instructed.
Avoid accidental overdosing; make a schedule when you have taken medicine or when you have to take it. Maintain a diary to help you keep track of your dosing schedule. An overdose of the drug may cause blurred vision, trouble speaking, tremors, stomach pain, sweating, seizures, confusion, and extreme weakness. Contact your healthcare specialist if you suspect an overdose. Continue taking diabetes medication for as long as your doctor prescribes it. Continued use is recommended for optimal benefits. If you miss a dose of Istavel, take it as soon as you remember. Avoid taking two doses to make up for a missed dose.
What is Istavel 25mg used for?
Istavel 25mg contains sitagliptin 25mg — the lowest available dose of this DPP-4 inhibitor, specifically for patients with moderate-to-severe chronic kidney disease (CKD, eGFR 30–45 ml/min). At this reduced dose, sitagliptin provides meaningful blood glucose control while avoiding accumulation in patients who cannot excrete full doses normally. It improves type 2 diabetes management in CKD — a population where many diabetes medications are contraindicated or require significant dose adjustment.
Why is sitagliptin 25mg used in kidney disease?
Sitagliptin is primarily cleared through the kidneys. In moderate-to-severe CKD (eGFR 30–45 ml/min), drug clearance is significantly reduced, causing accumulation at standard doses. The 25mg dose is calculated to provide appropriate sitagliptin exposure in patients with this level of renal impairment. DPP-4 inhibitors like sitagliptin are among the safest glucose-lowering agents in CKD — they do not cause hypoglycaemia and are not associated with lactic acidosis (unlike metformin) or deteriorating renal function.
When and how should Istavel 25mg be taken?
Istavel 25mg is taken once daily, with or without food, at any consistent time of day. The dose does not need to be split — once daily provides adequate 24-hour DPP-4 inhibition even at this reduced dose. Consistent daily timing improves adherence and maintains stable drug levels. As renal function changes, the dose should be reassessed — if eGFR improves to ≥45 ml/min, dose can be increased to 50mg; if it falls below 30 ml/min, some guidelines recommend a further dose reduction to 12.5mg.
Is sitagliptin 25mg effective in patients on dialysis?
For patients with severely reduced renal function (eGFR <30 ml/min) or on haemodialysis, an even lower dose of sitagliptin (12.5mg) is recommended in some guidelines. The 25mg dose is primarily intended for eGFR 30–45 ml/min. DPP-4 inhibitors are generally preferred in CKD and dialysis patients over sulfonylureas (hypoglycaemia risk) and metformin (lactic acidosis risk). Sitagliptin is minimally removed by dialysis and once-daily dosing without regard to dialysis timing is appropriate.
Is Istavel 25mg safe to use in CKD patients?
Yes — sitagliptin is one of the safest glucose-lowering agents in CKD. It does not cause hypoglycaemia when used alone, does not worsen renal function, and has been specifically dose-adjusted for renal impairment. The TECOS trial included patients with moderate CKD and demonstrated cardiovascular safety. Renal function should be monitored at least every 3–6 months in CKD patients using sitagliptin to ensure the correct dose is being maintained as function evolves.
Who should not take sitagliptin 25mg?
Sitagliptin at any dose is contraindicated in type 1 diabetes and DKA. It is used with caution and careful monitoring in severe CKD (eGFR <30 ml/min) and should be avoided in end-stage renal failure without specialist guidance. History of pancreatitis is a relative contraindication. Known hypersensitivity to sitagliptin is an absolute contraindication. In patients with heart failure, sitagliptin (unlike saxagliptin) appears safe per cardiovascular outcome trial data.
How does sitagliptin 25mg compare to gliclazide 40mg in CKD?
Sitagliptin 25mg is preferred over sulfonylureas like gliclazide in CKD (chronci kidney disease) patients. Gliclazide is renally cleared (though among safer sulfonylureas in CKD), and carries hypoglycaemia risk — particularly dangerous in CKD where hypoglycaemia epiSodiumes are associated with increased mortality. Sitagliptin does not cause hypoglycaemia, does not worsen renal function, and requires simple dose adjustment by dose reduction rather than discontinuation. Most diabetes guidelines prioritise DPP-4 inhibitors over sulfonylureas in moderate-severe CKD.
Is Istavel 25mg the same as low-dose Januvia?
Yes. Istavel 25mg contains sitagliptin 25mg — the same active ingredient as Januvia 25mg (the dose-adjusted formulation sold by MSD/Merck for CKD patients). Both are manufactured to bioequivalence standards with equivalent renal dose-adjusted efficacy. Istavel is the generic version, available at significantly lower cost than branded Januvia — important for CKD patients on multiple complex medications.
Can I order Istavel 25mg from PremiumRxDrugs for international delivery?
Yes. PremiumRxDrugs.com ships Istavel 25mg to the USA, UK, Australia, and many other countries. Their genuine manufacturer-verified medicines, transparent pricing, and free worldwide shipping on qualifying orders make them a reliable pharmacy for patients with CKD requiring dose-adjusted diabetes therapy.
What side effects does sitagliptin 25mg cause?
Sitagliptin 25mg shares the same side effect profile as higher doses, though the lower dose may have lower incidence. Common effects include nasopharyngitis (cold-like symptoms), upper respiratory tract infections, headache, and GI discomfort. Rare serious events: pancreatitis (severe abdominal pain — seek urgent care), bullous pemphigoid (blistering skin rash), and severe allergic reactions (anaphylaxis, angioedema). Hypoglycaemia does not occur with sitagliptin monotherapy.
What precautions apply to Istavel 25mg in CKD patients?
Monitor eGFR every 3–6 months in CKD — adjust dose if renal function changes significantly. Report severe persistent abdominal pain immediately (pancreatitis). Report blistering skin lesions (bullous pemphigoid). Ensure all healthcare providers know you have CKD when prescribing any new diabetes medication. Avoid dehydration (worsens CKD and drug clearance). Be aware of hypoglycaemia risk if sitagliptin is used alongside insulin or sulfonylureas in CKD patients.
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