Ivabrand 7.5 mg (Ivabradine)

Ivabradine is formulated for the symptomatic treatment of chronic stable angina pectoris in patients who are in sinus rhythm and can’t take beta blockers or have an intolerance to beta blockers. Its active component Ivabradine is a novel and useful addition to the class of anti-ischemic medications. The medicine works to lower the heart rate, which is helpful in treating both angina and heart failure. By slowing the heart rate, the heart needs oxygen, thereby minimizing the risk of an angina attack to develop. This is extremely useful at times when angina would be more likely to occur, such as during an exercise session or times of other physical work.

What is Ivabrand used for?

Ivabrand is a medicine available for the management of patients with angina pectoris, but it should only be taken when your symptoms are not controlled with optimized gold standard anti-ischemic therapy.

How does Ivabrand work?

Reduction of heart rate is an important part managing patients with coronary artery disease. Ivabrand allows a simultaneous reduction in oxygen demand and an increase in oxygen supply as well as redistribution of myocardial blood flow. Ivabradine, the active ingredient of the medicine works by inhibiting the If current, which regulates the intrinsic pacemaker activity in the sinoatrial node. The heart rhythm is slowed accordingly.

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What does Ivabrand contain?

Ivabrand contains the active ingredient Ivabradine, which is useful in treating symptoms of chronic angina. It reduces the pain related to angina by slowing down the heart beat.

What are the side effects of Ivabrand?

The following are the side effects that have been commonly reported by patients taking Ivabrand tablets:

• Blurred vision
• Dizziness
• Headache
• Slow heart rate
• Uncontrolled blood pressure
• Luminous visual phenomena

Some rare and uncommon side effects are given below:

• Low blood pressure
• Rash
• Vertigo
• Feeling weak or tired
• Shortness of breath
• Elevated levels of creatinine in the blood
• A vision problem such as double vision
• Palpitations
• Fainting
• Muscle cramps
• Raised levels of white blood cells (eosinophilia).
• Allergic reaction involving swelling of the face, throat, or tongue

The side effects that are explained above are not the only ones that you may experience due to Ivabrand medicine. If you get any side effect that troubles you, contact your physician right away.

What medications interact with Ivabrand?

If you need to take any of the following medicines while taking Ivabrand 7.5 mg, your heart function will need to be closely monitored.

• Antidepressants such as escitalopram, citalopram, clomipramine
• Antiarrhythmics such as sotalol, dronedarone, amiodarone, quinidine, amiodarone
• Antimicrobials like moxifloxacin, pentamidine, clarithromycin, or erythromycin
• Antimalarials like riamet, halofantrine, mefloquine
• Antipsychotics like sertindole, haloperidol, pimozide, thioridazine

The following medicines should not be taken in combination with Ivabrand:

• Macrolide antibiotics such as telithromycin, erythromycin, clarithromycin
• Azole antifungals like itraconazole, ketoconazole
• Protease inhibitors used for HIV infection such as ritonavir, nelfinavir
• Nefazodone

When should Ivabrand not be used?

Ivabrand is contraindicated in the following conditions:

• AV block
• Sick sinus syndrome
• Severe hypotension and bradycardia or cardiogenic shock
• Acute coronary syndromes
• SA block

Use it with extreme caution in patients who have altered or cardiac conduction.

How should Ivabrand be taken?

Ivabrand is available in the form of a tablet. The initial recommended dose is 5 mg twice daily. Your physician may increase your dose to 7.5 mg two times a day if required to control symptoms. If the heart rate of  a patient drops below 50 beats per minute at rest, the dose should be reduced. In addition, symptoms related to the bradycardia, such as hypotension, fatigue, and dizziness should be monitored on a regular basis.

There is no need of dose adjustment in patients with kidney impairment whose creatinine clearance is above 15ml/minute. Although, no data is available for those with creatinine clearance below 15ml/min and the medicine should therefore be used carefully in patients with renal insufficiency.

No dose adjustment is needed for patients with liver impairment. Exercise caution while using Ivabrand tablets in patients with moderate liver impairment and should not be used in patients with severe liver problems.

The tablet should be taken with food because food delays absorption by one hour and increases plasma exposure by 25%.

How long should you take Ivabrand?

You need to take Ivabrand 7.5 mg for long period and take on a regular basis at the same time so you do not miss the dose. Do not stop Ivabradine treatment unless your health care specialist advises you to do.

Missed dose of Ivabrand

If you forget to take a dose of Ivabrand to slow heartbeat, don’t take extra tablets or a double dose to compensate the missed dose. It is very important to ask your physician for advice on how to start the treatment again.

How should Ivabrand be stored?

Keep your tablets away from children and pets. Store the medicine at controlled room temperature.