Kombiglyze XR 5/500 mg (Saxagliptin Metformin)

 Kombiglyze XR 5/500 mg is formulated as an anti-diabetic medicine and it is intended to regulate the blood sugar levels in the patients with Type 2 diabetes. Moreover, this drug is indicated as an adjunct to diet and exercise so that patients can have better control over diabetes. By controlling high blood sugar, you can prevent several health conditions such as blindness, loss of limps’ function, kidney damage, nerve problems, and sexual dysfunction. Kombiglyze XR is a prescription drug and the adult patients. It is approved by the U.S. Food and Drug Administration.

Working of Kombiglyze XR:

In the condition of Type 2 diabetes, our body does not release sufficient insulin needed to control blood sugar. This medicine works by increasing the levels of natural substances called incretins in the body. These substances are powerful to control blood sugar by increasing the production of insulin. At the same time, it works to reduce the amount of sugar in your liver. Kombiglyze XR 5/500 can also be taken in combination with other medicines such as insulin or an SGLT2 inhibitor like dapagliflozin along with diet and exercise in order to treat Type 2 diabetes.

 Active Ingredient of Kombiglyze XR

Kombiglyze XR is a prescription medicine and it contains two major active ingredients – saxagliptin and metformin hydrochloride. Each tablet of Kombiglyze XR 5/500 has 5 mg saxagliptin and 500 mg metformin hydrochloride. Saxagliptin belongs to a group of medicines called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors), and metformin is related to a class of medicines called biguanides. Both the ingredients work together to lower blood sugar levels in patients with type 2 diabetes mellitus.

Side Effects of Kombiglyze XR:

Some probable side effects of Kombiglyze XR 5/500 include:

• Headache
• Diarrhea
• Upper respiratory tract infection
• Nausea and vomiting
• Urinary tract infection

Some allergic or hypersensitivity reactions of this medicine may be noticed as:

• Swelling of face, lips, throat, and other areas on the skin
• Breathing shortness and difficulty with swallowing
• Hives
• Slow or irregular heartbeat
• Upper respiratory tract
• Infection

Taking this medicine with meals can help lower the risks for the common stomach side effects. Those consumers who experience stomach pains, nausea, or vomiting should contact a doctor, as these sign may lead to the conditions that are more serious.

Medications interact with Kombiglyze XR:

If you are taking other medicines, including non-prescription medicines and food supplements, tell your doctor before taking Kombiglyze XR 5/500. There are some antibiotics, anti-fungal medicines and that may interact with this medicine. Some common medications checked in a combination of metformin/saxagliptin are amlodipine, aspirin, atorvastatin, Crestor, furosemide, gabapentin, glimepiride, lisinopril, and tramadol.

Not to use Kombiglyze XR if you are:

• are pregnant or breastfeeding
• have type 1 diabetes
• have problems with kidney function
• are allergic to its active ingredients
• have high blood triglyceride levels
• experience severe allergic reactions like swelling of the face, lips, throat and skin areas
• feel difficulty in breathing or swallowing
• have a skin rash, itching, flaking or peeling of the skin
• have metabolic acidosis or diabetic ketoacidosis
• feel fatigue
• have trouble breathing

How should Kombiglyze XR 5/500 be used?

Kombiglyze XR tablets are taken orally. Its dosage should be taken as per the doctor’s instructions. Usually, its tables are taken with food to lessen an upset stomach. It is swallowed with water. Do not halve, crush or chew Kombiglyze XR tablets before taking.

Medication course of Kombiglyze XR 5/500

For a successful treatment, you have to complete the full course as per your doctor’s instruction. Stick to the prescribed diet and exercise program while taking this medicine.

Missed dose of Kombiglyze XR:

If you have missed taking your regular dose of this medicine, do not take a double dose. It is recommended to take the next dose at the scheduled time, and consult your doctor if you have taken an overdose.