Mikacin– 500 mg Injection (Amikacin sulfate)

Mikacin is formulated to treat a wide variety of certain bacterial infections. These may include infections of the respiratory tract, gastrointestinal tract, urinary tract, skin infections, and infections of the bones and blood. It comprises of the active component Amikacin sulfate, which belongs to the aminoglycoside family of antibiotics. The medicine should be administered intravenously as it is poorly absorbed if taken orally. It has the ability to kill a broad range of bacteria. It van be purchased only on the prescription of a physician.

Mikacin general information

What is Mikacin used for?

Mikacin is designed to treat serious bacterial infections for which treatment with less toxic anti-infective agents is known to be ineffective or contraindicated. It is indicated for the treatment of infections caused by certain bacteria such as Escherichia coli, Pseudomonas species, Proteus species, Klebsiella Enterobacter-Serratia species, Salmonella species, Providencia species, Citrobacter species, and Staphylococcus aureus. This injection may also be used for purposes not mentioned in this document.

How does Mikacin work?

Mikacin contains the active ingredient, which works by inhibiting protein synthesis in bacteria at the level of the 30S ribosome. It resists the action of enzymes that are known to inactivate aminoglycosides. In this way, it exerts bactericidal action against susceptible bacteria.

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What does Mikacin contain?

Mika in consist chiefly of Amikacin sulfates as the active ingredient. The active constituent is an antibiotic. Each vial holds 500 mg of Amikacin sulfate.

What are the side effects of Mikacin?

• Respiratory system disease: apnea
• Central nervous system disorders: vertigo, headaches, drowsiness.
• Neurological issues: enhanced neuromuscular blockade
• Miscellaneous problems: nephrotoxicity, hypersensitivity reactions.

What medications interact with Mikacin?

• Mikacin gets inactivated by penicillins when coadministered to patients with kidney disorders.
• Concurrent use with neuromuscular blockers and inhalation anesthetics may potentiate their effects.
• The toxicity of loop diuretics may increase if used along with Amikacin sulfate.
• The incidence of nephrotoxicity may increase with the administration of nephrotoxic drugs such as cisplatin, vancomycin, cephalosporins, amphotericin, or acyclovir.

When should Mikacin not be used?

• Mikacin should not be used in patients with known hypersensitivity to any of the ingredients present in the preparation.
• It is not suitable for patients who have hypersensitivity to other aminoglycosides or bisulfites.
• The safety has not been established in pediatric patients.

The injection should be used cautiously in patients with the following conditions:

• Neuromuscular disorders such as Parkinson’s disease or myasthenia gravis
• Pregnancy as it may cause fetal nephrotoxicity or deafness
• Neonates
• Renal impairment

How should Mikacin be used?

• In patients with kidney diseases, it is important to prolong the interval between doses. The dosing plan usually depends on the condition and the severity of the patient. It should be used along with clinical observations of the patient and should be changed as required.
• For the treatment of children, adults, and neonates, patients body weight should be measured to determine, in the correct dosage. This should be done under the supervision of a certified physician.
• The recommended dose is 15 mg/kg/day. It should be given at 7.5 mg/kg every 12 hours (divided doses).

How long should Mikacin be used?

Use Mikacin as long as your physician prescribes you to use. Take the medication exactly as instructed by the doctor. Do not use more or less of it other than your physician has prescribed.

Missed dose of Mikacin 

If you forget to take a dose of Mikacin 500 mg, skip the dose, and go to back to your normal dosing schedule in case if its too late. But, if it is less than one hour of skipping the dose, then go and use it. You are not supposed to administer too much of the medication to balance the missed one.

How should Mikacin be stored?

Store at the room temperature. Protect from direct light and heat. Discard unused product. Keep the vial away from the reach of children and pets to avoid accidental consumption the medicine. Keep it in original packet until it is time to take out the medicine.