Pangraf 5 mg (Tacrolimus)

Pangraf 5 mg is a prescription medicine that should be used under proper medical surveillance. It is formulated to prevent your body from rejecting a kidney, liver, or transplant. It lowers your body’s immune system, which helps your body fight against infection. Your immune system can also help fight or reject a transplanted organ such as kidney or liver. The medicine contains Tacrolimus as the active pharmaceutical ingredient.

What is Pangraf used for?

Pangraf is used to prevent organ rejection in patients who have undergone allergenic liver, heart, or kidney transplantation.

How does Pangraf work?

By inhibiting T-lymphocyte activation, Pangraf prevents transplanted organ rejection.

Where to buy Pangraf online?

Pangraf is available for oral administration in the form of tablets. It is available in the pack sizes of 30, 60, and 90. You can buy Pangraf 5 mg online from our website premiumrxdrugs.com at a quite affordable price.

What does Pangraf contain?

Each pangraf tablet contains 5 mg of the active component Tacrolimus.

What are the side effects of Pangraf?

• Cardiovascular system disorders- Peripheral edema, hypertension
• Dermatological issues-alopecia, pruritus, rash
• Respiratory system disorders- cough, pharyngitis, pulmonary edema, bronchitis, asthma, pneumonia, pleural effusion
• Central nervous system disorders- abnormal dreams, confusion, hallucinations, confusion, somnolence, tremor, headache, insomnia, seizures, psychoses depression, and emotional lability.
• F and E disorders- hyperkalemia, hypomagnesemia, hyperlipidemia, hypophosphatemia, hyponatremia, metabolic alkalosis, hypocalcemia, hyperuricemia, metabolic acidosis
• Neurological issues- neuropathy, paresthesia
• Gastrointestinal issues- dyspepsia, constipation, vomiting, nausea, abdominal pain, constipation, gastrointestinal bleeding, diarrhea, ascites, increased liver enzymes, cholestatic jaundice, cholangitis, dysphagia flatulence, rexia, increased appetite oral thrush
• Endocrine disorders- hyperglycemia
• Genitouterine issues- urinary tract infection, nephrotoxicity
• EENT disorders- amblyopia, abnormal vision, tinnitus
• Hematological issues-thrombocytopenia, anemia, leukopenia, leukocytosis, pure red cell aplasia, coagulation defects
• Musculoskeletal disorders- leg cramps, hypertonia, arthralgia
• Miscellaneous issues- fever, chills, allergic reaction, including anaphylaxis, abnormal healing, the risk of skin cancer, generalized pain

What medications interact with Pangraf?

• The risk of nephrotoxicity is increased by concurrent use of cyclosporine, amphotericin B, aminoglycosides, or cisplatin
• Hyperkalemia may occur with concurrent use of ACE inhibitors, angiotensin II receptor antagonists, and potassium-sparing diuretics. 
• Vaccination may be less effective if taken along with Pangraf, therefore avoid the use of live-virus vaccines during the treatment with Tacrolimus.
• The following drugs may increase the levels of Pangraf:

1. calcium channel blockers
2. Danazol
3. Methylprednisolone
4. Coriconazole
5. Cyclosporine
6. Clarithromycin
7. Omeprazole
8. Cimetidine
9. Bromocriptine
10. Azole  antifungals
11. Magnesium hydroxide
12. Aluminum hydroxide
13. Protease inhibitors
14. Lansoprazole
15. Chlorophenicol

• The following drugs can decrease Tacrolimus blood levels:

1. Rifamycins
2. Sirolimus
3. Phenobarbital
4. Caspofungin
5. Phenytoin
6. Carbamazepine

• Avoid use of St.john’s wort medicine may decrease tacrolimus blood levels.
• Coadministration of Echinacea, astragalu and melatonin with Pangraf may interfere with immunosuppressants

When should Pangraf not be used?

• Pangraf is not suitable for patients who are hypersensitive to Tacrolimus or castor oil present in the formulation.
• It should be avoided by breastfeeding women.

Use it carefully in the following condition:

• Renal or hepatic impairment
• Exposure to UV light
• Pregnancy

How should Pangraf be taken?

• Patients are instructed to use the medicine daily on a regular basis as directed by your healthcare specialist. Patients are advised to read the prescription before starting the treatment carefully.
• Symptoms of rejection for transplanted organ and stress should be reviewed and notify your health care specialist if they occur.
• To avoid photosensitivity, patients are advised to wear protective clothing and sunscreen.
• One should avoid exposure to mumps, rubella, and chicken pox. If accidently exposed, see a health care professional for prophylactic therapy.
• Make sure that you do not share this medicine with anybody, since they may be suffering from a condition that is not effectively treated by this medicine.

How long should you take Pangraf?

Continue taking these 5 mg tablets for as long as your health care professional recommends.

Missed dose of Pangraf

Make sure that you do not skip or double up on missed doses. If you missed a dose, then talk to your health care specialist for further advice.

How long Pangraf is stored?

Keep the tablets out of the reach of children and away from pets. Don’t freeze the medicine. Store it at controlled room temperature.