Siphene 100 mg (Clomifene citrate)

Siphene tablets contain Clomifene citrate, a triphenylethylene nonsteroidal ovulatory stimulant assessed for antineoplastic activity against breast cancer. Your physician may also prescribe this anti-cancer agent for other conditions as well.

What is Siphene used for?

Siphene is an oral medication used to stimulate ovulation in non-ovulating women. It is also used to enhance the quality of ovulation, to correct luteal phase defects, and to ensure the proper timing of artificial insemination.

If you have any concerns about taking this drug, ask your physician. Siphene is not addictive. It does not interfere with your ability to drive a car or operate machinery.

You physician may have prescribed Siphene for another reason. Ask your physician, if you have any query about why this medicine has been prescribed for you.

How does Siphene work?

Siphene contains the active ingredient Clomifene citrate, which has both estrogenic and estrogenic activities. This agent competes with estrogen for adhering at estrogen receptor sites in target tissues. It causes the release of the pituitary gonadotropins follicle-stimulating hormone and luteinizing hormone, leading to ovulation.

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What does Siphene contain?

Siphene is a medicine containing Clomifene citrate. It acts as an antiestrogen. This active ingredient tricks the pituitary gland into producing the hormone that stimulates the ovaries. Clomifene is on the WHO model list of essential medicines, the most important medicines required in a basic health system.

What are the side effects of Siphene?

• The most common side effects are reversible ovarian enlargement and cyst formation, abdominal pain, vasomotor flushing resembling menopausal symptoms, increased urinary flow, and headache.
• Transient eye problems, such as blurred vision, spots or flashes may occur. Skin reactions, such as rashes and urticaria have also been associated with Siphene administration.
• Central nervous system disorders include: nervous tension, dizziness, fatigue, depression, insomnia, and vertigo, etc.
• Following treatment with Siphene, there is an increased risk of multiple births. This may affect the health of the newborn babies.
• The patients should be warned that visual signs may make driving or operate machinery more dangerous. If vision related problems occur, this medicine should be discontinued, and a complete ophthalmological assessment should be made.

Other side effects not mentioned above may also occur in some patients. Inform your physician, if you observe anything that is causing discomfort.

What medications interact with Siphene? 

Please tell your physician, if you are using any other drugs, including any that you buy without a prescription from the nearest pharmacy. However, Siphene has not been shown to interact with other medicines.

When should Siphene not be used?

Do not take Siphene if:

• You are allergic to any of the components contained in this tablet.
• You are pregnant
• You are breastfeeding
• You have a history of liver disease
• You have enlarged ovaries
• You have blood clot
• You have eye related problems
• You have abnormal vaginal bleeding
• You have hormone-dependent tumors
• You have a pituitary tumor
• You have uncontrolled thyroid disease

How should Siphene be taken?

• Careful evaluation and close attention to dosage instructions are important. Pelvic examination is necessary before each subsequent course of treatment.
• Ovulation most often occurs from 5-10 days after the treatment. Sexual intercourse should be timed to coincide with the expected time of ovulation.
• The recommended dosage is one 50 mg tablet every day for five days. If this dose is not effective, your physician may increase your dose to two tablets daily for five days. Do not take more than two tablets each day for five days.
• Take it with a glass full of water. If your physician has told you to take two tablets daily, take both the tablets at the same time instead of taking them at a different time.
• The patient should be assessed carefully to exclude ovarian enlargement, cyst formation, or pregnancy between each treatment cycle.
• If continuous uterine bleeding occurs, before Siphene treatment, the dosage of 50 mg daily for five days should be started on or about the fifth day of the cycle.

How long should you take Siphene?

Continue taking medicine for as long as your physician recommends. Do not miss doses. If you have trouble remembering your doses, please ask your physician for some tips.

Missed dose of Siphene

If you miss the dose of Siphene, take it whenever you remember, but if it is too late, then leave the missed dose and take the next dose at the correct scheduled time. Do not take an extra dose at the same time.

How should Siphene be stored?

• Keep the drug away from direct light and heat
• Place it away from the reach of children
• Do not store it in the bathroom or near a sink